How Long Does Ketamine Stay in Your System?

Updated December 22, 2025

An image of Karena Mathis, author for gratitude lodge
Authored By:

Karena Mathis

Edited By

Amy Leifeste

Medically Reviewed By

Sean O'Neill
MS, LMFT 112879

Explore treatment options today. For general drug info, contact your doctor.

How Long Does Ketamine Stay in Your System?

Updated December 22, 2025

Authored By:

Karena Mathis

Edited By

Amy Leifeste

Explore treatment options today. For general drug info, contact your doctor.

Ketamine is a potent dissociative anesthetic that was originally intended for medical use in animals and humans. The Schedule III controlled substance is commonly abused for its hallucinogenic effects.

This guide addresses one important issue: how long does ketamine stay in your system?

Ketamine Half-Life

For those wondering, โ€œWhat is the half-life of ketamineโ€, the ketamine elimination half life is around 3 hours. After this time, blood concentration levels of the drug will reduce by half. A substance is entirely eliminated from the system after five half-lives โ€“ up to 15 hours in the case of ketamine.

Despite its relatively short half-life, ketamine can be detectable in the body for an extended duration through various testing methods:

  • Saliva test: Ketamine can be identified in saliva for approximately 24 hours after consumption.
  • Blood test: Ketamine can be traced in the bloodstream for up to 3 days after ingestion, with optimal detection occurring within the first 24 hours.
  • Urine test: Ketamine remains detectable in urine for about 14 days, although some studies suggest detection may extend up to 30 days after the last use.
  • Hair test: Residues of ketamine can linger in the hair and hair follicles for as long as 4 months following a single instance of use.

Several factors can influence the duration of time ketamine remains detectable in your system:

  • Age and general health: Younger, healthier individuals tend to eliminate ketamine more rapidly due to their faster metabolisms.
  • Hydration levels: Ketamine primarily exits the body through urine. Therefore, individuals who maintain proper hydration and consequently urinate more frequently tend to eliminate ketamine more swiftly.
  • Metabolic rate: Individuals with a faster metabolic rate can break down and eliminate ketamine more efficiently than those with slower metabolisms.
  • Kidney and liver function: Efficient kidney and liver function are crucial for eliminating ketamine from the body. Impaired functioning of these organs can lead to a prolonged elimination process.
  • Body mass: Individuals with higher body mass can potentially metabolize ketamine more rapidly, as the amount of ketamine taken represents a smaller proportion of their overall body mass.
  • Dosage: Higher doses of ketamine can extend the time required for the body to eliminate the drug, as the system must work harder to process and expel it.
  • Frequency of use: Regular ketamine use can result in overlapping doses, causing the substance to accumulate in the body and prolonging the elimination process.
  • Concurrent drug use: Mixing ketamine with other substances can complicate the body’s detoxification process, as it must concurrently break down multiple substances, delaying the elimination of ketamine.
A man stares out the window wondering: how long does ketamine stay in your system?

Symptoms of Ketamine Withdrawal

If you or a loved one are struggling with ketamine addiction and trying to get sober, ketamine withdrawal can occur. While ketamine withdrawal can be different for everyone, there are common symptoms to look out for to determine if withdrawal is occurring.

The signs of ketamine leaving your system can include:

  • Cravings
  • Depression
  • Anxiety
  • Insomnia
  • Fatigue
  • Difficulty Concentrating
  • Mood Swings
  • Sweating/Chills
  • Nausea/Vomiting
  • Muscle Cramps
  • Body Aches

The severity of these symptoms can vary from person to person, depending on factors like length of use, amount being taken, and existing health status. If you or a loved one have decided to quit ketamine, seeking a treatment center that specializes in ketamine detox can provide the safest and most successful recovery.

Faqs

What Is Ketamine?

Ketamine is a dissociative drug that is used as an anesthetic by medical professionals. It is also frequently abused for its psychotropic effects.

How Long Does Ketamine Stay In Your Blood?

Ketamine can be detected in the blood for up to three days, although this can vary depending on factors such as dosage, frequency of use, and individual metabolism.

How Long Does Ketamine Stay In Urine?

Ketamine and its metabolites can be detectable in urine for up to six days. However, this may vary according to variables like individual metabolism and the amount of ketamine consumed.

How Long Is Ketamine In Your System After Ingesting?

The presence of ketamine in the body can be detected for up to four days. This timeframe can vary based on several factors, though, including the specific dose taken, the personโ€™s metabolism, and the frequency of use.

An image of the Gratitude Lodge facility where treatment for Ketamine addiction is available

Get Treatment For Ketamine Addiction At Gratitude Lodge

Now you know how long ketamine stays in your system, how can you go about addressing the abuse of this dangerous drug?

First, consider our supervised medical detox program at Gratitude Lodge in Southern California. You can access continuous clinical and emotional care as you withdraw from ketamine under controlled conditions. You will then move into ongoing inpatient treatment at one of our pet-friendly facilities in Newport Beach or Long Beach, CA.

Treatment programs at Gratitude Lodge utilize these interventions:

Call 844-576-0144 when you are ready to live substance-free.

Sources

  1. https://www.deadiversion.usdoj.gov/schedules/

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