April 2, 2024

What Is an SNRI?

therapy session representin snri

SNRIs – serotonin and norepinephrine reuptake inhibitors – are a class of drugs which have received FDA approval for the treatment of depression, GAD (generalized anxiety disorder), and fibromyalgia. SNRI drugs work by maintaining the level of certain chemical messengers in the brain. SNRIs are among the most widely prescribed antidepressants.

SNRIs (Serotonin and Norepinephrine Reuptake Inhibitors)

SNRIs were developed to treat depression more effectively than SSRIs (selective serotonin reuptake inhibitors), although this has not been conclusively demonstrated in scientific studies.  

Individual responses to antidepressants vary, with some people benefiting more from one type of medication. Some research suggests that SNRIs can be as effective as tricyclic antidepressants but with significantly fewer side effects.

SNRIs can alleviate depression by influencing neurotransmitters. Neurotransmitters are chemical messengers that streamline communication between brain cells. Like most types of antidepressants, SNRIs achieve their effects by triggering alterations in brain chemistry and the communication within brain nerve cell networks which govern mood regulation.

SNRI antidepressants have a mechanism of action which blocks the reabsorption of serotonin and norepinephrine in the brain. This ensures that these neurotransmitters remain more active, leading to improvements in mood and a reduction in depressive symptoms.

image representing Serotonin and norepinephrine reuptake inhibitors

Differences Between SNRI vs. SSRI

SNRIs and SSRIs are antidepressant medications with different mechanisms of action used to treat the same conditions.

SSRIs focus on preventing the reabsorption of serotonin in the brain, increasing concentrations of this neurotransmitter in the brain. SNRIs boost levels of serotonin, too, as well as levels of norepinephrine. These unique mechanisms of action can trigger slightly different side effects.

SNRI Side Effects

SNRIs are associated with mild side effects that tend to dissipate within the first few weeks of treatment. Some people may experience no side effects at all. The most common side effects of SNRIs include:

  • Nausea
  • Dizziness
  • Dry mouth
  • Headaches
  • Sweating

Less common side effects may include:

  • Constipation
  • Fatigue
  • Insomnia
  • Decreased sex drive
  • Appetite loss

If one SNRI triggers unmanageable side effects, another might be more tolerable due to differences in chemical composition.

In most cases, the advantages of using antidepressants significantly outweigh the drawbacks. Consult your healthcare provider for targeted advice on the side effects associated with specific SNRIs.

SNRI Withdrawal

Antidepressant discontinuation syndrome may occur when someone abruptly discontinues use of an SNRI after using the medication for six weeks or more. The symptoms most commonly associated with SNRI withdrawal include:

  • Flu-like symptoms
  • Nausea
  • Insomnia
  • Dizziness
  • Lightheadedness
  • Sensory disturbances
  • Irritability
  • Agitation
  • Anxiety

Although the symptoms of SNRI withdrawal are not generally severe, they can nevertheless be distressing and aggravating. It is inadvisable to abruptly stop using this class of medication, even if you feel that your symptoms have subsided. The safest method of discontinuing use involves a gradual and tapered reduction in dosage under close medical supervision.

Antidepressant discontinuation is not like withdrawal from addictive substances like alcohol or opioids, and it does not involve cravings to use the medication – antidepressants do not cause physical dependence. Read on to discover how to connect with compassionate and evidence-based mental health treatment if you need help recalibrating your life.

FAQs

What is an SNRI?

AN SNRI is a class of medications mainly used to treat depression and anxiety disorders. These medications work by increasing levels of serotonin and norepinephrine in the brain. Serotonin and norepinephrine play an important part in mood regulation.

What does SNRI stand for?

SNRI stands for serotonin and norepinephrine reuptake inhibitor. This refers to the medication’s mechanism of action in preventing the reabsorption of both neurotransmitters, enhancing their effects on mood and emotional well-being.

Is Wellbutrin an SNRI?

No, Wellbutrin is not an SNRI. It is classified as an NDRI (norepinephrine and dopamine reuptake inhibitor). The medication does not impact serotonin levels.

inside view of gratitude lodge's facility representing Serotonin and norepinephrine reuptake inhibitors

Get Treatment for Depression & Addiction at Gratitude Lodge

If you require treatment for addiction and mental health issues, reach out to Gratitude Lodge in Southern California.

When addictions and mental health conditions like depression co-occur, integrated dual diagnosis treatment delivers the best outcomes. When you engage with inpatient treatment at our rehabs in Long Beach or Newport Beach, you can begin by withdrawing from drugs or alcohol under medical supervision.

During ongoing inpatient treatment, you can access an individualized blend of the following interventions:

  • Medication-assisted treatment
  • Motivational therapies
  • Psychotherapies
  • Family therapy
  • One-on-one counseling
  • Group therapy
  • Holistic treatments
  • Aftercare support

Call Gratitude Lodge at 800-994-2184 for effective depression and addiction treatment.

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Joe Gilmore

Joseph Gilmore

Joseph Gilmore has been working in the addiction industry for half a decade and has been writing about addiction and substance abuse treatment during that time. He has experience working for facilities all across the country. Connect with Joe on LinkedIn.
Jenni Bussi

Jenni Busse MS, LPCC

Jenni Busse MS, LPSS is the Clinical Director at Gratitude Lodge. Jenni oversees the clinical program and the clinical team at Gratitude Lodge as a whole. Jenni has worked in treatment for almost 14 years. Her background as a licensed therapist and her passion for helping others intersected with addiction recovery when she started working primarily in detox residential treatment.

Drug detox can vary according to the patient’s addiction factors, including the substance abused, how long the addiction has lasted, the patient’s medical condition, if any other disorders are present, and more. Our skilled and credentialed team at Gratitude Lodge work closely with every patient going through drug detox, facilitating the beginnings of a successful recovery at our rehab addiction centers in Orange County, CA.

Drug detox can vary according to the patient’s addiction factors, including the substance abused, how long the addiction has lasted, the patient’s medical condition, if any other disorders are present, and more. Our skilled and credentialed team at Gratitude Lodge work closely with every patient going through drug detox.

Many patients don’t realize the toxicity of prolonged alcohol abuse and how it affects the body. Alcohol detox at the luxurious rehab addiction centers at Gratitude Lodge leeches your body of these toxins in preparation for successful treatment for drugs and alcohol abuse. Alcohol detox may not take as long or produce severe withdrawal symptoms, but it is still an essential beginning to your recovery.

Many patients don’t realize the toxicity of prolonged alcohol abuse and how it affects the body. Alcohol detox at the luxurious rehab addiction centers at Gratitude Lodge leeches your body of these toxins in preparation for successful treatment for drugs and alcohol abuse.

Holistic Therapy

Our holistic therapy treatments offer a full-scope approach to recovery, addressing your mind, body, and emotions as part of a comprehensive treatment plan. This therapy is designed to help address underlying issues and integrate alternative therapies to promote overall health and well-being.
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Psychotherapy

An essential part of your treatment experience, we offer individual (CBT and DBT talk therapy) and group addiction treatment counseling to help you explore and address the emotional component of addiction, providing you with the tools, self-awareness, and empowerment you need to maintain recovery.

Dual Diagnosis

Dual Diagnosis is a highly effective addiction treatment that addresses substance use and mental health disorders simultaneously. Often co-occurring, these disorders are best managed when treated together with specific and targeted therapy.
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Medication-Assisted Treatment (MAT)

Medication-Assisted Treatment provides you with FDA-approved medications to help ease the symptoms of withdrawal while you’re in treatment. This makes the detox process easier and safer, as well as increasing the chances of a successful recovery.

Sober Living

Sober living provides a supportive and substance-free living environment for your ongoing recovery. We partner with a number of upscale and carefully vetted sober living homes that are available to our clients after inpatient alcohol and drug addiction treatment.
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Outpatient Treatment

Once detox and inpatient are complete, we provide an easy transition to outpatient care through our hand-selected partners. This program offers a more flexible approach, allowing you to ease back in to daily life while still receiving frequent & effective care.
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Inpatient treatment provides an intensive and comprehensive addiction treatment program in a structured environment. You will receive 24/7 expert care, therapy, and support as you build your foundation for long-term recovery.

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A crucial first step in the recovery process, our detox program provides a comfortable, medically supervised environment that addresses the physical aspect of addiction and eliminates substances from your body.

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