March 4, 2024

Oxycodone Withdrawal: Signs, Symptoms, & Treatment

an image of someone who got help for oxycodone withdrawal

Withdrawal from oxycodone, a potent opioid painkiller, is associated with the presentation of symptoms like nausea, vomiting, aches, and pains.

Although the symptoms of oxycodone withdrawal can be effectively managed with supervised detoxification, attempts to detox from opioids at home can be dangerous and potentially deadly. Read on to discover more about the oxycodone withdrawal timeline and discover how to connect with evidence-based care.

Oxycodone Withdrawal Signs

Oxycodone, a powerful opioid contained in many prescription painkillers, rapidly leads to the development of tolerance, meaning that increased doses are required for the same pain relief.

Developing physical dependence on oxycodone means that discontinuing its use can trigger severe and possibly painful withdrawal symptoms. The intensity of these symptoms can cause some people to relapse, while others might keep using oxycodone simply to maintain a sense of normalcy and stave off withdrawal.

While the symptoms of oxycodone withdrawal are mainly physical and psychological experiences of the individual, there are some key signs that manifest as a direct result of these withdrawal symptoms. These signs are more specifically related to the withdrawal process itself, rather than broader indicators of addiction. Recognizing these signs can help in identifying when someone is going through withdrawal and may need support or medical attention. These signs include:

  • Restlessness: An inability to stay still, pacing, or seeming uncomfortable, often due to body aches and anxiety.
  • Appetite changes: A sudden decrease in appetite, which may lead to noticeable weight loss over a short period.
  • Flu-like symptoms: The manifestation of severe flu-like symptoms, such as fever, chills, and sweating, without the presence of an actual flu virus.
  • Agitation and irritability: A noticeable increase in irritability or agitation, which can be a direct response to discomfort and distress during withdrawal.
  • Sleep disturbances: Presenting as either insomnia or disrupted sleep patterns, including frequent awakenings or intense nightmares.
  • Yawning and sneezing: Excessive yawning and sneezing that goes beyond normal levels, which are distinct physiological reactions to withdrawal.
  • Pupil dilation: Noticeable dilation of the pupils, a physiological sign that often accompanies opioid withdrawal.
  • Heightened pain sensitivity: An increased sensitivity to pain, where even minor physical discomforts are felt more acutely.
  • Emotional fluctuations: Sudden and intense emotional responses, including bouts of crying or despair, as part of the psychological withdrawal process.

These signs of oxycodone withdrawal are important indicators that someone is experiencing the acute phase of withdrawal and might require medical support to safely manage these symptoms. Understanding these signs helps in providing timely and appropriate care to those undergoing withdrawal, ensuring a safer and more comfortable transition towards recovery.

Oxycodone Withdrawal Symptoms

Withdrawal of oxycodone symptoms usually start to manifest between 8 to 12 hours after the last use of opioids. The severity of these symptoms often correlates with the frequency and volume of use, with chronic, heavy use typically triggering more intense effects. Oxycodone withdrawal shares many characteristics with heroin withdrawal, presenting primarily as flu-like in nature.

The range of common withdrawal symptoms includes, but is not limited to:

  • Body aches and pains
  • Sweating
  • Teary eyes
  • Runny nose
  • Coughing
  • Fatigue
  • Depression
  • Anxiety
  • Shaking
  • Increased heart rate
  • Nausea and vomiting
  • Diarrhea
  • Irritability
  • Mood swings
  • Difficulty concentrating
  • An inability to experience pleasure

Given that oxycodone is the active compound in medications like OxyContin and Percocet, the withdrawal symptoms for these drugs are similar, affecting people in comparable ways regardless of the specific brand consumed.

How long is oxycodone withdrawal, then?

Oxycodone Withdrawal Timeline

The oxycodone withdrawal timeline closely aligns with the timeline associated with heroin withdrawal. Although everyone has a different experience of opioid withdrawal, this is a typical oxycodone withdrawal timeline:

Initial 48 hours

Symptoms manifest between 8 to 12 hours after the last consumption. These may include

  • Restlessness and rapid breathing
  • Intense cravings for the drug
  • Nausea
  • Muscle and joint discomfort
  • Headaches
  • Fatigue
  • Appetite loss
  • Anxiety
  • Irritability

Days 3 to 5

This phase of the oxycodone withdrawal timeline is normally marked by the peak intensity of withdrawal symptoms that include:

  • Vomiting
  • Persistent nausea
  • Shaking
  • Cramps
  • Continuing muscle aches

Days 6 to 7

As the physical symptoms subside, psychological symptoms may become more pronounced. These can include:

  • Nausea
  • Diarrhea
  • Heightened anxiety
  • Emerging depression

Days 8 to 21

By this stage of the oxycodone withdrawal timeline, the body is almost fully purged of opioids, although some may still experience lingering symptoms.

The journey through oxycodone withdrawal demands a structured support system and medical oversight. Options for treatment range from inpatient or outpatient care to MAT (medication-assisted treatment) and counseling, all integral to a safe and effective recovery process. Engaging with a healthcare provider for individualized advice and support is key to navigating this challenging period with the necessary resources and care.


How long does oxycodone withdrawal take?

The oxycodone withdrawal timeline may vary, but symptoms typically begin within 8 to 12 hours after the last dose, peak around 72 hours, and can last from 1 week to 1 month for acute symptoms. Some people may encounter protracted withdrawal symptoms, known as PAWS (post-acute withdrawal syndrome), that may persist for months.

How is oxycodone withdrawal treated?

Oxycodone withdrawal is treated through a combination of medical detox, which may include medications like methadone, buprenorphine, or clonidine to ease symptoms, and support therapies such as counseling and support groups. Treatment plans are personalized, and some may require inpatient or outpatient rehabilitation programs.

What is oxycodone withdrawal like?

Oxycodone withdrawal can be intensely uncomfortable and includes symptoms such as anxiety, insomnia, sweating, muscle aches, nausea, and vomiting. Psychological symptoms like depression and cravings are also common. The severity and duration of withdrawal symptoms can vary based on the duration of use, dosage, and individual health factors.

Should I go to a treatment center for oxycodone withdrawal?

Yes, seeking treatment at a specialized center for oxycodone withdrawal is often recommended because these centers provide medical supervision, which can make withdrawal safer and more comfortable. Treatment centers also offer a structured environment with access to therapy and support systems that can significantly improve the chances of a successful recovery.

Get Treatment for Oxycodone Withdrawal at Gratitude Lodge

A risk of overdose and addiction are among the side effects of oxycodone that require professional intervention. We can help you with all aspects of opioid abuse at Gratitude Lodge in Southern California.

Opioid withdrawal can be aggravating and potentially life-threatening if unsupervised. Now that you know how long will oxycodone withdrawal last, choose the safest and most comfortable pathway to ongoing recovery by engaging with medical detox at one of our pet-friendly rehabs in Long Beach or Newport Beach, CA.

Following detoxification, you can move into ongoing inpatient treatment where you will address the psychological side of opioid addiction. Expect to access personalized treatments that may include:

  • Talk therapies like CBT and DBT
  • MAT (medication-assisted treatment)
  • Holistic interventions
  • Group therapy
  • Individual counseling
  • Family therapy
  • Aftercare and support

When you are committed to tackling oxycodone addiction, call 800-994-2184 for immediate assistance.

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Joe Gilmore

Joseph Gilmore

Joseph Gilmore has been working in the addiction industry for half a decade and has been writing about addiction and substance abuse treatment during that time. He has experience working for facilities all across the country. Connect with Joe on LinkedIn.
Jenni Bussi

Jenni Busse MS, LPCC

Jenni Busse MS, LPSS is the Clinical Director at Gratitude Lodge. Jenni oversees the clinical program and the clinical team at Gratitude Lodge as a whole. Jenni has worked in treatment for almost 14 years. Her background as a licensed therapist and her passion for helping others intersected with addiction recovery when she started working primarily in detox residential treatment.

Drug detox can vary according to the patient’s addiction factors, including the substance abused, how long the addiction has lasted, the patient’s medical condition, if any other disorders are present, and more. Our skilled and credentialed team at Gratitude Lodge work closely with every patient going through drug detox, facilitating the beginnings of a successful recovery at our rehab addiction centers in Orange County, CA.

Drug detox can vary according to the patient’s addiction factors, including the substance abused, how long the addiction has lasted, the patient’s medical condition, if any other disorders are present, and more. Our skilled and credentialed team at Gratitude Lodge work closely with every patient going through drug detox.

Many patients don’t realize the toxicity of prolonged alcohol abuse and how it affects the body. Alcohol detox at the luxurious rehab addiction centers at Gratitude Lodge leeches your body of these toxins in preparation for successful treatment for drugs and alcohol abuse. Alcohol detox may not take as long or produce severe withdrawal symptoms, but it is still an essential beginning to your recovery.

Many patients don’t realize the toxicity of prolonged alcohol abuse and how it affects the body. Alcohol detox at the luxurious rehab addiction centers at Gratitude Lodge leeches your body of these toxins in preparation for successful treatment for drugs and alcohol abuse.

Holistic Therapy

Our holistic therapy treatments offer a full-scope approach to recovery, addressing your mind, body, and emotions as part of a comprehensive treatment plan. This therapy is designed to help address underlying issues and integrate alternative therapies to promote overall health and well-being.
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An essential part of your treatment experience, we offer individual (CBT and DBT talk therapy) and group addiction treatment counseling to help you explore and address the emotional component of addiction, providing you with the tools, self-awareness, and empowerment you need to maintain recovery.

Dual Diagnosis

Dual Diagnosis is a highly effective addiction treatment that addresses substance use and mental health disorders simultaneously. Often co-occurring, these disorders are best managed when treated together with specific and targeted therapy.
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Medication-Assisted Treatment (MAT)

Medication-Assisted Treatment provides you with FDA-approved medications to help ease the symptoms of withdrawal while you’re in treatment. This makes the detox process easier and safer, as well as increasing the chances of a successful recovery.

Sober Living

Sober living provides a supportive and substance-free living environment for your ongoing recovery. We partner with a number of upscale and carefully vetted sober living homes that are available to our clients after inpatient alcohol and drug addiction treatment.
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Outpatient Treatment

Once detox and inpatient are complete, we provide an easy transition to outpatient care through our hand-selected partners. This program offers a more flexible approach, allowing you to ease back in to daily life while still receiving frequent & effective care.
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Inpatient treatment provides an intensive and comprehensive addiction treatment program in a structured environment. You will receive 24/7 expert care, therapy, and support as you build your foundation for long-term recovery.

Drug & Alcohol Detox

A crucial first step in the recovery process, our detox program provides a comfortable, medically supervised environment that addresses the physical aspect of addiction and eliminates substances from your body.

Use Our 24 Hour text line. You can ask questions about our program, the admissions process, and more.