September 18, 2023

Is Mixing Alcohol and Zoloft Dangerous?

Woman looks out a window representing Alcohol and zoloft .

Can you drink alcohol on Zoloft” is one of the questions most commonly asked by those prescribed this antidepressant.

Help for you or a loved one is only one call away.

Zoloft (sertraline) is a prescription drug categorized as an SSRI (selective serotonin reuptake inhibitor), a class of antidepressants. Much like other SSRIs, Zoloft works by altering the reabsorption of the neurotransmitter serotonin within the brain.

This guide highlights the main Zoloft and alcohol side effects. You will also learn about the following issues related to alcohol and Zoloft:

  • Can you drink alcohol while taking Zoloft?
  • Can you drink on Zoloft on a special occasion?
  • What are the adverse effects of Zoloft and drinking?
  • How to engage with alcohol addiction treatment.

Zoloft and Alcohol Interaction

The interaction between Zoloft and alcohol is a topic that warrants careful consideration and awareness. Here are some key points to consider about the Zoloft alcohol interaction:

Amplification of side effects

Both Zoloft and alcohol can independently lead to drowsiness, dizziness, and impaired coordination. When you drink on Zoloft, these effects are often intensified, significantly increasing the risk of accidents and falls.

Reduced medication efficacy

Alcohol can compromise the effectiveness of Zoloft in treating depression and anxiety. When alcohol is present in the system, it may hinder the medication’s ability to regulate serotonin levels in the brain, potentially limiting the therapeutic benefits.

Risk of increased depressive symptoms

Alcohol is a central nervous system depressant. Its consumption can worsen depressive symptoms like sadness, hopelessness, and lethargy. This counteracts the positive effects of Zoloft and can lead to a worsening of the person’s mental health condition.

Potential for serotonin syndrome

Both Zoloft and alcohol can influence serotonin levels in the brain. When taken together, there exists a theoretical risk of developing serotonin syndrome. This rare but serious condition can manifest with symptoms like confusion, rapid heart rate, high blood pressure, fever, and even seizures.

Individual variability

The impact of the Zoloft-alcohol interaction can vary among individuals. Factors such as the dosage of Zoloft, the quantity and frequency of alcohol consumption, and individual differences in metabolism can all influence the severity of the interaction.

Risk of alcohol dependency

Individuals with depression may be more vulnerable to alcohol misuse as a way of self-medicating their symptoms. The combination of Zoloft and alcohol can increase the risk of developing alcohol dependency, leading to further complications.

Potential for increased sedation

Alcohol can amplify Zoloft’s sedative effects. This may result in excessive drowsiness and difficulty staying awake, especially when engaging in activities that require alertness, such as driving.

In light of these considerations, healthcare providers generally advise people taking Zoloft to avoid alcohol altogether. Prioritizing mental health and adhering to the prescribed treatment plan is crucial. If individuals have concerns about alcohol use and its impact on their depression, they should discuss these concerns openly with their healthcare provider. Together, they can explore alternative coping strategies and treatment options that do not involve alcohol.

image of woman representing zoloft and alcohol interaction

Alcohol’s Effects on Depression

Alcohol and depression have a complex relationship. While alcohol is sometimes used as a means of self-medication to alleviate depressive symptoms temporarily, its overall impact on depression can be detrimental. Here are some key points to consider:

  • Temporary relief: Alcohol can provide a temporary sense of relief from the emotional pain associated with depression. It may initially produce feelings of relaxation and euphoria, which can seem like a welcome escape from depressive thoughts and emotions.
  • Depressive cycle: Unfortunately, the relief offered by alcohol is short-lived. As the effects wear off, depressive symptoms often return, and they can intensify. This can create a vicious cycle where individuals may turn to alcohol repeatedly in an attempt to alleviate their depression, leading to a harmful pattern of substance abuse.
  • Alcohol as a depressant: Alcohol is a CNS depressant. It slows down brain activity and can exacerbate symptoms of depression, such as sadness, lethargy, and impaired cognitive function.
  • Sleep disruption: Alcohol can disrupt sleep patterns, leading to poor sleep quality. Sleep problems are closely linked to depression, and the combination of alcohol and sleep disturbances can worsen depressive symptoms.
  • Increased risk: For individuals with depression, alcohol use can increase the risk of suicidal thoughts and behaviors. The impaired judgment and impulsivity associated with alcohol can lead to risky behaviors.
  • Interaction with medications: Alcohol can interact with antidepressant medications, including drugs like Zoloft. This interaction may reduce the effectiveness of the medication and potentially lead to adverse side effects.

So, while alcohol may offer momentary relief from depression, it ultimately worsens the condition and increases the risk of substance abuse and other negative outcomes. It is imperative for individuals with depression to seek professional help and consider healthier coping strategies and treatment options that do not involve alcohol. Always consult with a healthcare provider for personalized guidance on managing depression and any potential interactions between alcohol and medication.


What happens if you drink on Zoloft?

Drinking alcohol while taking Zoloft can increase the risk of side effects like dizziness, drowsiness, and impaired coordination. It can also diminish the effectiveness of Zoloft in treating your condition. Consult your healthcare provider before combining Zoloft and alcohol.

Can I mix sertraline and alcohol?

It is generally recommended to avoid alcohol while taking sertraline (Zoloft). Alcohol can interact with the medication, potentially intensifying side effects and reducing its effectiveness in treating depression or anxiety. Consult your healthcare provider for personalized guidance.

Can Zoloft and alcohol kill you if they’re mixed?

Zoloft and alcohol death may occur, but it is an uncommon outcome. That said, combining these substances can trigger severe side effects and health risks. Drinking alcohol while on Zoloft may increase the likelihood of accidents, worsen depressive symptoms, and impact your overall well-being.

an image of Gratitude Lodge's drink on zoloft treatment center

Get Treatment for Alcohol Addiction and Depression at Gratitude Lodge

Alcohol addiction and depression frequently co-occur, with each condition feeding the other. At Gratitude Lodge in Southern California, we specialize in inpatient dual diagnosis treatment, providing the most structured and supportive route to sustained recovery and sound mental health.

Engage with our supervised medical detox program for the safest and most comfortable pathway to ongoing recovery. After a week or so of detoxification, you can move straight into residential rehab at our treatment facilities located in Long Beach and Newport Beach, CA.

All treatment programs at Gratitude Lodge involve a personalized blend of holistic and science-backed interventions like:

Take the first steps toward sustained sobriety by calling 888-861-1658 today.

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Joe Gilmore

Joseph Gilmore

Joseph Gilmore has been working in the addiction industry for half a decade and has been writing about addiction and substance abuse treatment during that time. He has experience working for facilities all across the country. Connect with Joe on LinkedIn.
Jenni Bussi

Jenni Russe MS, LPCC

Jenni Busse MS, LPSS is the Clinical Director at Gratitude Lodge. Jenni oversees the clinical program and the clinical team at Gratitude Lodge as a whole. Jenni has worked in treatment for almost 14 years. Her background as a licensed therapist and her passion for helping others intersected with addiction recovery when she started working primarily in detox residential treatment.

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