What Is the Opioid Epidemic?

Updated February 10, 2026

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Authored By:

Karena Mathis

Edited By

Amy Leifeste

Medically Reviewed By

Sean O'Neill
MS, LMFT 112879

Explore treatment options today. For general drug info, contact your doctor.

What Is the Opioid Epidemic?

Updated February 10, 2026

Authored By:

Karena Mathis

Edited By

Amy Leifeste

Explore treatment options today. For general drug info, contact your doctor.

The opioid epidemic, also known as the opioid crisis, describes the dramatic rise in the excessive use, abuse of opioids and opiates since the 1990s, as well as the associated overdose deaths.

Read on to discover what started the opioid epidemic and how this crisis continues and evolves. You can also find out how you can get help if someone you know is addicted to this class of medication.

Opioid Crisis Overview

The U.S. opioid epidemic is an evolving public health crisis thatโ€™s unfolded over several decades, beginning in the late 1990s. Initiated by the widespread over-prescription of opioid painkillers like oxycodone and hydrocodone for those with chronic pain, the crisis was driven by the misleading claims of pharmaceutical companies regarding the non-addictive nature of opioids. This misinformation led to a surge in prescription opioid misuse, setting off the first wave of the epidemic that has claimed more than one million lives in the past two decades.

The situation gained traction when a 2011 press release from CDC (Centers for Disease Control and Prevention) included a comment from then-director Thomas Friedman, MD. about an โ€œepidemic of overdoses.โ€ This acknowledgment spurred the healthcare and public health systems into action, resulting in stricter prescribing guidelines and legal restrictions aimed at curbing opioid misuse. While these efforts saw some success in stabilizing prescription opioid-related deaths, the rates did not significantly decrease in a sustained manner. Also, despite these early warnings from CDC, it was not until 2017 that the opioid epidemic was declared a public health emergency.

Indeed, as prescription controls became stricter, a second wave emerged in 2010 that was marked by a sharp uptick in heroin use and deaths related to this illicit narcotic. Many people who became dependent on opioids sought alternatives when unable to refill prescriptions or unable to afford the ongoing cost of prescription opioids.

Drug traffickers pounced on this phase of the opioid crisis to flood the market with heroin, followed by a shift toward fentanyl โ€“ a synthetic opioid 50 times stronger than heroin and much easier to produce and smuggle. The introduction of fentanyl marked the epidemicโ€™s third wave in 2013, triggering an unprecedented spike in overdose deaths due to the extreme potency of fentanyl and its analogs.

By 2015, a fourth wave had begun, a phase of the crisis associated with the lethal combination of fentanyl and stimulants.

woman deep in thought representing When did the opioid epidemic begin

When Did the Opioid Epidemic Begin?

The opioid epidemic began in the late 1990s when pharmaceutical companies began marketing opioids to healthcare providers on a nationwide scale, falsely claiming that these medications were not addictive. This led to a significant increase in prescriptions for pain management, setting the foundation for widespread misuse and the subsequent public health crisis that continues to evolve today.

Opioid Epidemic Timeline

  1. First wave: The onset of the epidemic in the 1990s was mainly fueled by an increase in the prescribing of opioids for the management of chronic pain. This led to a rise in overdose deaths linked to prescription opioids, including natural and semi-synthetic opioids, as well as methadone.
  2. Second wave: In 2010, the epidemic took a deadly turn with a sharp increase in heroin-related overdose deaths. This wave was partly attributed to efforts to control prescription opioid abuse, pushing many toward cheaper and more accessible heroin.
  3. Third wave: The situation worsened in 2013 with a surge in deaths involving synthetic opioids, particularly illicitly manufactured fentanyl.
  4. Fourth wave: Beginning in 2015, fatalities involving fentanyl combined with stimulants rose sharply.

Opioid Epidemic Statistics

The following opioid epidemic statistics sourced from NIDA illustrate the scope and severity of the crisis:

  1. Total overdose deaths: In 2021 alone, there were over 106,000 drug-involved overdose deaths in the U.S.
  2. Gender disparities: Approximately 69% of overdose cases occurred among males.
  3. Rise of synthetic opioids: Deaths involving synthetic opioids spiked dramatically between 2015 and 2021.
  4. Opioid-related deaths: More than 80,000 deaths were attributed to opioids in 2021.
  5. Stimulant-related deaths: Deaths involving stimulants like cocaine and meth climbed to 53,495 in 2021.

What Is Causing the Opioid Epidemic?

The deceptive marketing tactics of pharmaceutical companies like Purdue Pharma were one of the primary causes behind the opioid epidemic. Aggressive marketing minimized addiction risks, leading to widespread prescribing and misuse of opioid medications.

A major turning point was the lawsuit by the state of Oklahoma against Purdue Pharma, which resulted in a $270 million settlement in 2019, acknowledging the companyโ€™s role in the epidemic. Other states pursued similar cases, resulting in Purdue paying billions in damages.

Although big pharma fueled the epidemic early on, today the crisis continues primarily due to fentanyl โ€” a substance so potent that only a few grains can be fatal.

What Can Be Done About the Opioid Epidemic?

  1. Ongoing action against fentanyl: Focused law enforcement, education, and harm reduction must continue.
  2. Stricter monitoring of prescriptions: Physicians must closely monitor opioid therapy.
  3. Public education: Teach the risks of opioid misuse and promote safer pain management alternatives.
  4. Expanded treatment access: Ensure treatment options like MAT, therapy, and support groups are widely available.
  5. Research funding: Invest in non-addictive pain relief and addiction studies.
  6. Naloxone access: Increase availability to first responders and the public.
  7. Overdose monitoring: Improve systems tracking overdose trends.
  8. Community support: Address underlying factors like employment, housing, and education.

FAQs

What Is the Opioid Epidemic?

The opioid epidemic refers to widespread misuse of opioid medications, causing rising addiction and overdose deaths. It was declared a public health emergency in 2017.

What Caused the Opioid Epidemic?

The opioid epidemic was caused by deceptive pharmaceutical marketing, over-prescription, and socioeconomic factors that increased vulnerability to addiction.

Is the Opioid Epidemic Over?

No. Despite policy changes and treatment expansion, opioid misuse and overdose deaths remain high.

people laughing together representing What caused the opioid epidemic

Get Treatment for Opioid Addiction at Gratitude Lodge

Even though the abuse of prescription opioids has declined, the opioid epidemic continues โ€” especially due to fentanyl combined with stimulants.

Begin recovery with supervised detox at our luxury facilities in Long Beach and Newport Beach, CA.

After detox, youโ€™ll transition to inpatient treatment, where youโ€™ll receive:

  1. Holistic treatments
  2. Individual counseling
  3. Talk therapy
  4. MAT
  5. Group therapy
  6. Family therapy
  7. Aftercare support

Call 844-576-0144 for immediate assistance.

Sources

  1. https://www.cdc.gov/nchs/hus/topics/drug-overdose-deaths.htm
  2. https://archive.cdc.gov/#/details?url=https:/www.cdc.gov/media/releases/2011/p1101_flu_pain_killer_overdose.html
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378105/
  4. https://www.dea.gov/factsheets/fentanyl
  5. https://www.cdc.gov/overdose-prevention/glossary/?CDC_AAref_Val=https:/www.cdc.gov/opioids/basics/terms.html
  6. https://nida.nih.gov/research-topics/trends-statistics/overdose-death-rates

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