Antidepressants addiction is a common concern among those who are prescribed medications to treat major depressive disorder. Antidepressants are medications that alter the brain’s chemical balance to address mood disorders like depression. People who misuse antidepressants may be contending with substance addiction issues separate from their antidepressant use.
This guide to antidepressants and addiction outlines issues that include:
- Are antidepressants addictive?
- How does addiction to antidepressants develop?
- Addicted to antidepressants: how to engage with treatment in Southern California.
Can You Get Addicted to Antidepressants?
Addiction to antidepressants differs from addiction to substances like alcohol or heroin. It lacks the cravings, euphoria, and negative consequences often associated with traditional drug addiction. That said, physical dependence can develop in individuals using antidepressants regularly, leading to withdrawal symptoms when use is abruptly reduced or discontinued.
Antidepressant dependence can even occur in individuals who were initially misdiagnosed with depression and prescribed these medications unnecessarily.
However, antidepressants do not produce a significant euphoric rush or cravings that typically drive addiction to other substances.
Some individuals attempt to misuse antidepressants by snorting them, although this does not typically lead to addiction and may only occur when the preferred substance is unavailable, offering little more than a placebo-like effect.
Despite the risks associated with antidepressants, these medications significantly improve the lives of many individuals. Anyone prescribed antidepressants should never discontinue them without consulting a doctor.
Best Antidepressant for Drug Addicts
The choice of the best antidepressant for individuals with a history of substance abuse, including drug addiction, can vary depending on the specific needs and circumstances of the person. There is no one-size-fits-all answer, as everyone’s situation is unique. That said, some factors and considerations to keep in mind when selecting an antidepressant for someone with a history of drug addiction include:
- Type of substance abuse: The choice of antidepressant may depend on the type of substance that was abused. Some antidepressants may interact differently with certain drugs or alcohol.
- Co-occurring disorders: Individuals with a history of drug addiction often have co-occurring mental health conditions, such as depression or anxiety. It is imperative to choose an antidepressant that can effectively treat both the addiction and the co-occurring disorder.
- Safety profile: Some antidepressants have a better safety profile when it comes to potential interactions with drugs or alcohol. Selecting an antidepressant with a lower risk of adverse effects when combined with substances of abuse is crucial.
- Potential for abuse: Consider the potential for abuse or misuse of the antidepressant itself. Some antidepressants have a lower potential for abuse than others.
- Medical history: The individual’s medical history, including any previous adverse reactions to antidepressants or other medications, should be considered.
- Individual response: Response to antidepressants varies among individuals. It may be necessary to try different antidepressants to find the one that works best for a particular person.
- Monitoring and support: Close monitoring by a healthcare professional and adequate support in the form of therapy or counseling are essential components of treatment for individuals with a history of drug addiction.
Commonly prescribed antidepressants for individuals with a history of substance abuse include SSRIs (selective serotonin reuptake inhibitors) like sertraline (Zoloft) and escitalopram (Lexapro) and SNRIs (serotonin-norepinephrine reuptake inhibitors) like venlafaxine (Effexor). However, the choice should be made in consultation with a healthcare provider who can assess the individual’s specific needs and tailor the treatment accordingly.

Antidepressant Addiction Symptoms
Antidepressant addiction is not as common as addiction to other substances like opioids or alcohol, but it can still occur. The symptoms of antidepressant addiction or dependence can vary from person to person, but some common signs and symptoms to watch for include:
- Compulsive use: Individuals may find themselves taking antidepressants more frequently or in higher doses than prescribed, even after their mood has stabilized.
- Craving: Some people may develop a psychological craving for the antidepressant and feel like they need it to function normally.
- Loss of control: Those addicted to antidepressants may have difficulty controlling their use, even when they want to cut down or stop taking the medication.
- Neglecting responsibilities: As with any addiction, people may neglect their responsibilities at home, work, or school because they are preoccupied with obtaining or using antidepressants.
- Social isolation: A person addicted to antidepressants may withdraw from social activities, friends, and family.
- Doctor shopping: Some people may seek prescriptions for antidepressants from multiple doctors or engage in deceptive practices to obtain more of the medication.
- Continued use despite harm: Even if they experience negative consequences, individuals addicted to antidepressants may continue to use them.
- Withdrawal symptoms: Withdrawal may include anxiety, irritability, flu-like symptoms, and mood disturbances.
- Tolerance: Over time, higher doses may be needed to achieve the same effect.
- Mood swings: Frequent and severe mood swings can occur, especially when the medication is not taken.
Not everyone who takes antidepressants will develop an addiction or dependence. Most people take these medications as prescribed without issues. Consult a healthcare professional if signs of addiction appear.
Antidepressant Addiction Treatment
Treatment typically involves medical assessment, psychological therapies, and behavioral interventions. Plans vary depending on severity and circumstances.
A healthcare provider will conduct a thorough medical assessment to determine the extent of dependence and identify co-occurring disorders.
Medically supervised detox may be required when tapering antidepressants.
- CBT or DBT to address underlying issues and build coping strategies.
- Group sessions providing peer support.
- Medication management for co-occurring mental health disorders.
- Behavioral therapies to identify triggers and coping strategies.
- Support groups such as 12-step programs.
- Relapse prevention training.
- Complementary therapies like mindfulness, yoga, and exercise.
Seek help from professionals experienced in antidepressant addiction and co-occurring disorders.
FAQs
Are Tricyclic Antidepressants Addictive?
TCAs are not addictive like opioids or stimulants, but abrupt discontinuation can cause withdrawal.
Are All Antidepressants Addictive?
Most modern antidepressantsโsuch as SSRIs and SNRIsโare not addictive in the traditional sense.
What Is the Best Treatment for Depression for Drug Addicts?
Treatment varies but usually involves therapy, support groups, and individualized planning.
Is Depression and Addiction Connected?
Yes. Depression and addiction often coexist and reinforce each other, requiring integrated treatment.

Get Effective Treatment for Antidepressant Addiction at Gratitude Lodge
If you require assistance safely discontinuing the use of antidepressants, we can help at Gratitude Lodge Newport Beach or Long Beach, CA.
Begin recovery with our prescription drug detox program. After tapering safely, move into further treatment.
Gratitude Lodgeโs 30-day inpatient program offers:
- Medication-assisted treatment
- Psychotherapies like CBT or DBT
- Group therapy
- Individual therapy
- Family therapy
- Holistic therapy
- Aftercare
Stop using antidepressants safely and comfortably. Call 844-576-0144.
Sources
- https://www.samhsa.gov/medications-substance-use-disorders/medications-counseling-related-conditions/co-occurring-disorders
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552465/
- https://www.nimh.nih.gov/health/topics/psychotherapies
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678283/













