Lexapro (escitalopram) is frequently prescribed for managing conditions such as major depressive disorder and generalized anxiety disorder. While rare, it is possible to overdose on Lexapro, which may occur due to accidental ingestion, intentional misuse, or drug interactions. This guide explores the following issues:

• Can you overdose on Lexapro?
• What are the risks of suicidal ideation on Lexapro?
• What happens if you take too much Lexapro by mistake?
• What happens if you overdose on Lexapro?
• Can overdosing on Lexapro kill you?

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What is Lexapro?

Lexapro, the brand name for the antidepressant drug escitalopram, is classified as an SSRI (selective serotonin reuptake inhibitors). SSRIs are widely recognized and commonly prescribed to treat depression and other mental health disorders (ex, generalized anxiety disorder, panic disorder, and major depressive disorder).

This class of medication interacts with the neurotransmitter serotonin, which plays a crucial role in regulating various bodily functions such as mood, sleep, memory, appetite, and digestion – all of which can be affected in individuals with depression.

By increasing serotonin levels in the brain, Lexapro functions to alleviate depression symptoms and improve overall mood. While the medication is generally considered safe when used as directed, it is possible to overdose on Lexapro.

Can You Overdose on Lexapro?

Can you OD on Lexapro, then? A Lexapro overdose can occur when someone surpasses the recommended prescribed dosage. The standard initial dose for Lexapro, regardless of age, is typically 10mg once daily, as outlined by the FDA (U.S. Food and Drug Administration). During clinical trials, though, overdose symptoms were reported in cases where participants consumed doses as high as 600mg of Lexapro, although no lethal effects were observed. The potential for overdose can vary based on a variety of factors.

Additionally, combining Lexapro with substances that are Monoamine Oxidase Inhibitors (MAOIs) or serotonergic drugs can be hazardous. Lexapro does not mix well with these medications because they all increase serotonin levels, which can lead to a potentially life-threatening condition known as serotonin syndrome. Symptoms of serotonin syndrome include agitation, rapid heart rate, high blood pressure, confusion, and loss of muscle coordination.

To prevent this risk, MAOIs should not be taken with Lexapro or within two weeks of discontinuing either medication. To avoid Lexapro overdose, always consult your healthcare provider before combining this medicine with any other drugs.

Lexapro and the Risk of Suicidal Ideation

The relationship between Lexapro and suicidal ideation remains a topic of ongoing research and intense debate. Some studies show no significant increase in suicide risk—while others suggest that younger patients (under 25 years old) may be at a higher risk of experiencing suicidal thoughts or behaviors when starting antidepressant treatment (such as Lexapro)[7]. Due to life-threatening concerns around suicidal ideation, the FDA has issued black box warnings about this risk, emphasizing the importance of monitoring mood changes, particularly in the first few weeks of treatment.

In contrast, research also indicates that antidepressants may lower suicide risk in adults over 65, which suggests an age-dependent variability in antidepressant use[7]. However, the reasons behind this variability and the link between antidepressant use and the onset or worsening of suicidal thoughts remain inconclusive. This gap in research underlines the need for ongoing studies and improved education for both prescribers and patients as the use of antidepressants continues to grow.

If you or someone you know is experiencing worsening depression or suicidal thoughts while taking Lexapro, seek immediate medical attention or call the National Suicide Prevention Lifeline (988 in the U.S.).

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What Happens When You Overdose on Lexapro?

While escitalopram overdose cases are infrequent, they are possible. The consequences of overdosing on Lexapro are contingent on several factors, including the amount ingested, the duration of usage, the person’s weight, and any concurrent use of other substances.

Common overdose symptoms of Lexapro can include:

• Bradycardia (slow heart rate): A dangerously reduced heart rate that can impair blood flow and oxygen delivery.
• Confusion: Disorientation or difficulty thinking clearly, often accompanied by memory issues.
• Dilated pupils: Unusually large pupils are often a sign of nervous system disruption or overdose.
• Fever: Elevated body temperature that can indicate your body’s attempt to fight infection.
• Dizziness: A feeling of unsteadiness or lightheadedness which impairs balance.
• Insomnia: Difficulty falling or staying asleep, often leading to fatigue.
• High blood pressure: Elevated blood pressure levels due to overdose increase the risk of heart problems.
• Nausea and vomiting: Gastrointestinal distress and vomiting are common overdose symptoms.
• Convulsions: Sudden, involuntary muscle contractions or seizures caused by abnormal brain activity.
• Coma: A prolonged state of unconsciousness resulting from severe overdose or other critical conditions.
• Serotonin syndrome: Studies suggest that approximately 14% to 16% of SSRI overdoses may lead to serotonin syndrome [8]. This condition, a serious complication of SSRI overdose, occurs when serotonin levels rise beyond a normal or healthy range due to excessive neurotransmitter activity. If left untreated, serotonin syndrome can be life-threatening, causing symptoms such as agitation, insomnia, confusion, rapid heart rate, high blood pressure, and loss of muscle coordination.

An overdose of Lexapro is much more likely when the medication is combined with other substances, such as alcohol, other prescription medications, or illicit narcotics. While most people disclose other medications they are taking to their doctors to prevent interactions, some individuals intentionally mix antidepressants with substances like alcohol to induce intoxication. This practice of polysubstance abuse is dangerous and can result in Lexapro overdose death. Always adhere to prescribed medication guidelines.

If you observe Lexapro overdose symptoms in yourself or someone else, call 911 immediately.

How to Get Help for a Lexapro Overdose

If you suspect a Lexapro overdose, seek immediate medical attention. The first and most critical step is to call emergency services or your local poison control center as soon as an overdose is suspected. Be prepared to provide detailed information about the person’s age, weight, the amount of Lexapro taken, time of ingestion, and any other medications ingested. This information helps medical professionals determine the best course of action quickly.

Upon arrival at a medical facility, healthcare providers will monitor vital signs, such as heart rate, blood pressure, and oxygen levels, to assess the severity of the overdose. In many cases, activated charcoal may be administered to prevent further drug absorption in the digestive system. This is most effective if given shortly after ingestion. Specific medical attention, including medications to counteract symptoms, may be used for severe symptoms, such as serotonin syndrome or seizures.

Supportive care is a cornerstone of overdose treatment and may involve intravenous fluids, oxygen therapy, or medication to stabilize vital functions. Advanced interventions such as intubation or cardiac monitoring may be required in life-threatening cases. Early medical intervention is essential to counteract symptoms and support recovery.

Recovery from a Lexapro overdose typically requires a comprehensive approach that involves ongoing medical support and mental health treatment. To streamline this process, follow the guidance of healthcare providers closely and attend any follow-up appointments or therapy sessions as recommended.

Remember that even though a Lexapro overdose can be alarming, timely intervention and proper medical management can significantly improve the chances of a successful recovery.

To Prevent the Risk of Lexapro Overdose

To prevent the risk of Lexapro overdose, follow these important precautions:

• Stick to your prescribed dose: Do not exceed your prescribed Lexapro dose, and do not make any adjustments without consulting your healthcare provider, even if you feel that your current dose is inadequate.
• Avoid combining with specific medications: Certain drugs and substances that affect serotonin levels should not be taken concurrently with Lexapro. These include:

• MAOIs (monoamine oxidase inhibitors): MAOIs must not be used alongside Lexapro or within two weeks of discontinuing Lexapro [6]. Combining them heightens the risk of serotonin syndrome. Examples of MAOIs include rasagiline, phenelzine, isocarboxazid, and intravenous methylene blue.
• Serotonergic drugs: Medications that influence serotonin levels in the brain can increase the risk of serotonin syndrome when combined with Lexapro. Serotonergic drugs include fentanyl, lithium, tramadol, tryptophan, triptans, tricyclic antidepressants, amphetamines, and buspirone.

• Discuss medications with your healthcare provider: Before starting Lexapro, thoroughly discuss current and recent medications with your healthcare provider. This should also include any over-the-counter or recreational drugs you may be using.
• Notify your healthcare provider or pharmacist: If you plan to introduce a new medication, inform your prescribing physician or pharmacist that you are taking Lexapro before commencing the new treatment.

Following these precautions and maintaining open communication with your healthcare provider can help ensure your safety and well-being while using Lexapro.

Get Help Today for Prescription Drug Addiction at Gratitude Lodge

Gratitude Lodge has treatment facilities in Southern California that offer specialized assistance in conquering substance dependencies and addressing mental well-being. With a focus on comprehensive healing, our rehab centers in Newport Beach and Long Beach, CA, warmly accommodate pets, allowing for a more holistic recovery journey.

Our closely monitored medical detox regimen allows you to taper off Lexapro gradually. Once your body successfully cleanses from addictive substances, you can move into ongoing, 30-day residential treatment. Our range of treatment strategies includes:

• MAT (medication-assisted treatment)
• Psychotherapy
• Group therapy
• One-on-one counseling
• Family therapy
• Group therapy
• Aftercare support

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Sources

1. https://medlineplus.gov/druginfo/meds/a603005.html
2. https://www.ncbi.nlm.nih.gov/books/NBK554406/
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634816/
4. https://www.fda.gov/
5. https://medlineplus.gov/ency/article/007272.htm
6. https://www.ncbi.nlm.nih.gov/books/NBK539848/