Wellbutrin is an antidepressant commonly used to treat major depressive disorder. Long-term use of this medication can lead to physical dependence and withdrawal symptoms upon quitting.

If you have concerns like how to stop Wellbutrin safely and avoid severe withdrawal symptoms upon Wellbutrin discontinuation, this guide addresses these issues and more. You can also learn how to connect with compassionate and effective [1] care for withdrawal from Wellbutrin.

What Is Bupropion (Wellbutrin) Withdrawal?

Wellbutrin is a branded form of bupropion, a popular antidepressant that can also help with other conditions like anxiety, ADHD, and bipolar disorder. It’s even used to help people quit smoking in the form of Zyban.

Wellbutrin offers many potential benefits but doesn’t work for everyone. One advantage of Wellbutrin over some other antidepressants is that it has a lower risk of causing withdrawal symptoms when you stop taking it. Bupropion withdrawal symptoms are physical reactions from a body that’s become dependent on the medication.

Some antidepressants, especially SSRIs [2], can cause a condition called antidepressant discontinuation syndrome [3], also known as withdrawal, which can be very uncomfortable.

Unlike SSRIs, which affect a brain chemical called serotonin, Wellbutrin works on different chemicals called dopamine and noradrenaline. Because of this, stopping Wellbutrin usually doesn’t cause severe withdrawal symptoms. If bupropion withdrawal symptoms occur, they are usually mild and can include:

• Excessive sweating

• Digestive problems

• Trouble sleeping

What Are Wellbutrin Withdrawal Symptoms?

While most people don’t have withdrawal symptoms when they stop taking Wellbutrin, some might experience side effects. Here are some possible withdrawal symptoms:

• Increased sweating: You might sweat a lot more than usual, especially in warm weather.

• Digestive issues: Some people feel nauseous, vomit, have diarrhea, or lose their appetite.

• Sleep problems: You may have trouble falling asleep or staying asleep, and sometimes you might have vivid or strange dreams.

• Shakiness: You might feel shaky, have restless legs, or experience numbness.

• Mood changes: Mood swings, agitation, anxiety, or even feelings of depression can occur.

• Brain zaps: These are sensations that feel like small electric shocks in the head [4], sometimes called brain shakes.

If you plan to stop taking Wellbutrin, talk to your doctor first. They can help you gradually reduce your dose and manage any withdrawal symptoms you might have.

What are Wellbutrin Missed Dose Symptoms?

If you miss a dose of Wellbutrin, you might notice some mild symptoms:

• Mood changes: You might feel more irritable or anxious than usual.

• Tiredness: You might feel more tired or have less energy.

• Headache: Missing a dose can sometimes cause headaches.

• Difficulty concentrating: It might be harder to focus or think clearly.

If you miss a dose, do not double up to make up for it. Just take your next dose at the regular time. If you have any concerns or notice symptoms, talk to your doctor for advice.

How Long Does Wellbutrin Withdrawal Last? A Withdrawal Timeline

If you experience withdrawal symptoms after stopping this medication, here’s a general bupropion withdrawal timeline of what to expect:

First few days

• Mild symptoms: You might feel a bit irritable, anxious, or have trouble sleeping.

• Headaches: Some people get headaches in the first few days.

Week 1

• Increased symptoms: You may notice more sweating, nausea, or changes in appetite.

• Mood changes: Feelings of agitation or mood swings might become more noticeable.

1 to 2 weeks

• Peak symptoms: This is when symptoms are usually the strongest. You might have trouble sleeping, feel very irritable, or experience brain zaps.

• Digestive issues: Nausea, vomiting, or diarrhea could occur during this time.

2 to 4 weeks

• Gradual improvement: Symptoms should start to get better. Mood swings and sleep problems may slowly decrease.

• Energy levels: You may begin to feel more like yourself, with your energy levels improving.

After 1 month

• Most symptoms fade: Most withdrawal symptoms should be gone or much milder. However, some people might still have slight mood changes or intermittent trouble sleeping.

Everyone is different, so the timeline can vary. Always talk to your doctor before stopping Wellbutrin to get the best advice for your situation. They can help you manage withdrawal symptoms and adjust your treatment plan if needed.

How to Stop Wellbutrin Safely

Stopping Wellbutrin involves gradually reducing the amount you take – see the taper schedule below.

The safest way to stop taking Wellbutrin is to slowly reduce your dose [7], a process called tapering. Tapering helps your body adjust to having less of the medication and can prevent withdrawal symptoms. Wellbutrin tapering schedules are usually short, often lasting one to two weeks.

Always work with your doctor to create a tapering plan that is right for you. They will help you gradually decrease your dose to make the transition smoother. By tapering your dose, you can safely stop taking Wellbutrin while minimizing any potential withdrawal symptoms. Always follow your doctor’s instructions during this process.

Wellbutrin Taper Schedule

To taper off Wellbutrin XL 150mg, your doctor might suggest a plan like this:

• First week: Reduce your dose to 150mg every other day.

• Second week: Take 150mg every three days.

• Third week: Stop taking Wellbutrin completely.

Your doctor will adjust this plan based on how you respond, so follow their advice closely.

Wellbutrin Half-Life

The duration of Wellbutrin withdrawal symptoms depends on how long the medication stays in your body, known as its half-life. The half-life is the time it takes for the amount of medication in your body to decrease by half. After five half-lives, almost all of the drug will be eliminated from the body. If you take Wellbutrin occasionally, the half-life is about three to four hours. However, when you take it daily as prescribed, the half-life extends to about 21 hours.

What Happens if You Stop Wellbutrin Cold Turkey?

Stopping Wellbutrin cold turkey can lead to withdrawal symptoms such as:

• Increased anxiety, irritability, or depression.

• Headaches, dizziness, and nausea.

• Trouble sleeping or vivid dreams.

Do not stop Wellbutrin abruptly. Always talk to your doctor before making any changes to your medication. They will help you taper off safely to avoid these unpleasant symptoms.

How to Know When to Seek Help

Here are some signs that you might need extra support when stopping Wellbutrin:

• Severe withdrawal symptoms: If your withdrawal symptoms are very strong or hard to handle, it’s time to get help. This can include extreme mood swings, severe anxiety, or intense headaches.

• Mental health changes: If you start feeling very depressed, have suicidal thoughts, or notice any significant changes in your mental health, contact your doctor immediately.

• Physical symptoms: If you experience persistent nausea, vomiting, or any other physical symptoms that don’t go away, you should seek medical advice.

• Difficulty managing: If you find it hard to manage daily tasks or feel overwhelmed, it’s a good idea to talk to a healthcare provider.

Getting help early can make the process of stopping Wellbutrin easier and safer. Your doctor can provide the support and guidance you need to streamline the process and reduce discomfort.

Ways to Prevent Symptoms

Preventing withdrawal symptoms can make stopping Wellbutrin much easier. Here are some ways to help prevent symptoms:

• Tapering: Gradually reducing your dose, as discussed with your doctor, can help prevent withdrawal symptoms [5].

• Stay hydrated: Drink plenty of water to help your body adjust.

• Healthy diet: Eating a balanced diet can keep your energy levels stable and help with any digestive issues.

• Regular exercise: Physical activity can improve your mood and help manage stress.

• Sleep routine: Maintaining a regular sleep schedule can help with insomnia or sleep disturbances.

• Stress management: Practice relaxation techniques like deep breathing, meditation, or yoga to manage stress.

By following these tips, you can help your body adjust to the change and reduce the likelihood of experiencing withdrawal symptoms.

Coping With Symptoms

When experiencing withdrawal symptoms from Wellbutrin, it’s useful to have strategies in place to help you cope. Here are some approaches you can take:

• Stay connected: Share your feelings and experiences with friends and family. Their support can provide comfort and encouragement. Find local or online support groups where you can connect with others going through similar experiences. Sharing stories and tips can be very helpful.

• Rest and relaxation: Ensure you get enough sleep each night. Rest helps your body heal and cope with withdrawal. Try deep breathing exercises, meditation, or yoga. These techniques can help reduce stress and anxiety.

• Healthy lifestyle: Drink water during the day. Staying hydrated can help reduce some side effects of stopping Wellbutrin like headaches and dry mouth. Consuming a variety of healthy foods can keep your energy levels stable and help with digestive issues. Include plenty of lean proteins, fruits and vegetables, and whole grains in your diet. Physical activity can boost your mood and help manage stress. Even light exercises like walking or stretching can make a big difference.

• Mental health support: Consider seeing a therapist who can provide professional support. CBT (cognitive behavioral therapy) is especially helpful for managing mood swings and anxiety – it can help you change the way you think and act. Practice mindfulness to stay grounded and focused [6]. This can help you manage any mental health changes you experience during withdrawal.

• For sleep problems: Create a relaxing bedtime routine to help you sleep better. Avoid screens before bed, keep your bedroom dark and quiet, and try reading or listening to calming music before sleeping.

• For digestive issues: Eat small, frequent meals instead of large ones. Ginger tea or peppermint can also help soothe nausea.

• For headaches: Rest in a dark, quiet room, and use a cold compress on your forehead. Over-the-counter pain relievers like ibuprofen can also help but check with your doctor before taking any new medication.

• Medication management: Adhere to the tapering plan provided by your doctor. This gradual reduction helps minimize withdrawal symptoms. Your doctor might prescribe medications to manage specific symptoms, such as anti-nausea drugs for digestive issues or sleep aids for insomnia. Always take these as directed.

• Monitor your progress: Write down your symptoms and any coping strategies you use. This can help you track what works and what doesn’t and provide useful information for your doctor. Schedule regular appointments with your doctor to discuss your progress and any concerns. They can adjust your tapering plan or suggest new coping strategies if needed.

• Emotional support: Try to stay positive and focus on the progress you’re making. Remind yourself that withdrawal symptoms are temporary and will pass with time. Celebrate small milestones in your tapering process. Treat yourself to something enjoyable, like a favorite meal or a relaxing activity, to maintain motivation.

By using these coping strategies, you can manage Wellbutrin withdrawal symptoms more effectively and make the transition smoother. Always keep in close contact with your healthcare provider throughout the process. If your symptoms become too severe to manage on your own, don’t hesitate to seek medical help. This includes symptoms like extreme mood swings, thoughts of self-harm, or severe physical symptoms. 

Detox Options for Wellbutrin

If you’re finding it difficult to stop Wellbutrin on your own, a detox program can provide the support you need. Detox programs offer medical supervision and support to help you safely stop taking the medication. Here are some options:

• Inpatient detox: This involves staying at a detox facility where you can receive 24/7 medical care and support. This is often the best option for severe withdrawal symptoms.

• Outpatient detox: You can visit a detox center for treatment during the day and return home at night. This option works well for those with milder symptoms.

• Medication-assisted detox: Some detox programs use medications to help reduce withdrawal symptoms and make the process more comfortable.

Detox programs provide a safe and supportive environment to help you stop taking Wellbutrin and begin your recovery journey. We offer a full range of detox services at Gratitude Lodge.

Get Compassionate Addiction Help at a World-Class Detox Facility, Gratitude Lodge

If you or someone you care about need help dealing with drug addiction, reach out to Gratitude Lodge. We offer detox services and inpatient treatment programs at our luxury facilities in Long Beach and Newport Beach, CA.

When you begin your recovery with detox at Gratitude Lodge, you can access medications to reduce cravings and withdrawal symptoms. You can also access 24/7 clinical and emotional care as you move from drug dependence to ongoing inpatient treatment at one of our rehabs by the beach.

Due to the unique nature of all addictions, our treatment programs deliver personalized therapies, such as:

• Counseling
• Talk therapies
• Medication-assisted treatment
• Motivational therapy
• Family therapy
• Holistic therapies
• Group therapy
• Aftercare

Call our recovery experts today to begin treatment at 844-576-0144.

Sources

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678283/

[2] https://www.ncbi.nlm.nih.gov/books/NBK554406/

[3] https://www.health.harvard.edu/diseases-and-conditions/going-off-antidepressants

[4] https://www.psychiatrist.com/news/study-tackles-the-mystery-of-brain-zaps-in-antidepressant-withdrawal/

[5] https://www.ccjm.org/content/89/1/18

[6] https://news.harvard.edu/gazette/story/2018/04/less-stress-clearer-thoughts-with-mindfulness-meditation/

[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181057/